A serological study on the antigenic relationships of the form genusTrichosporon

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Abstract
By means of antisera prepared from all recognized species of the form genus Trichosporon (Behrend), it was shown in agglutination, precipitation, agar-gel diffusion and complement-fixation tests with whole cell antigens and crude polysaccharide extracts that the various Trichosporon species can be subdivided in three, possibly four, serological groups. Strains belonging to sero-group 1 ( T. fermentans, T. capitatum, T. sericeum ) give numerous unilateral or reciprocal cross reactions with Geotrichum candidum and Nadsonia elongata . Strains of sero-group 2 ( T. cutaneum, T. infestans, T. margaritiferum ) show common partial antigens with Cryptococcus species, Candida curvata and Candida humicola. T. pullulans holds an intermediate position between sero-group 1 and 2. T. behrendii is serologically distinct from the remaining Trichosporon species. A tentative antigenic scheme for the form genus Trichosporon was developed. The results are in good agreement with earlier work of the senior author and indicate close phylogenetic relationships between the different Trichosporon species and various other form genera of yeasts and yeast-like fungi thereby confirming the views of Wickerham. The difficulties in the preparation of antisera are discussed and a combined method of immunization is presented.

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