Stimulation of Colonic Blood Flow by Pentagastrin

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Abstract
Pentagastrin, a synthetic gastrointestinal hormone, stimulates relative blood flow to the upper, middle and lower third of the rat colon by 2-, 4- and 6-fold, respectively. Much small inductive effects are seen in the lung (30% increase) and kidney (62% increase), while no significant effects on relative blood flow are observed in the liver after pretreatment with pentagastrin. These effects on blood flow are consistent with pentagastrin-induced effects on DNA synthesis and benzo[a]pyrene hydroxylation activity.