ANTIOXIDANT ACTIVITY OF PROBUCOL

  • 1 September 1989
    • journal article
    • research article
    • Vol. 39-2  (9) , 1090-1091
Abstract
To evaluate a possible antioxidant activity of probucol on NADPH-dependent microsomal lipid peroxidation and on iron-doxorubicin (adriamycin) complex-induced phospholipid peroxidation, the effects were compared with another powerful antioxidant, 2-OH-estrone. Antioxidant activity of 10 .mu.mol/l probucol in NADPH-dependent microsomal lipid peroxidation corresponded to 4 .mu.mol/l 2-OH-estrone. Together with the results obtained from iron-doxorubicin complex-induced phospholipid peroxidation, it was concluded that probucol is a potent inhibitor of lipid peroxidation and has one-quarter to one-half the antioxidant activity of 2-OH-estrone in vitro.

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