Multivariate genetic analysis of apo AI concentration and HDL subfractions: Evidence for major locus pleiotropy

1 January 1993

journal article
research article
Published by Wiley in Genetic Epidemiology

Vol. 10 (6) , 617-622
https://doi.org/10.1002/gepi.1370100648

Abstract

A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins.

Keywords

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