Curling of Flap Tips in HIV-1 Protease as a Mechanism for Substrate Entry and Tolerance of Drug Resistance

This publication has 30 references indexed in Scilit:

• Structural and biochemical studies of retroviral proteases
  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000
• Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function
  Structure, 1999
• Structure of HOE/BAY 793 Complexed to Human Immunodeficiency Virus (HIV‐1) Protease in Two Different Crystal Forms Structure/Function Relationship and Influence of Crystal Packing
  European Journal of Biochemistry, 1997
• Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants
  Proceedings of the National Academy of Sciences, 1997
• Development of Drug Resistance to HIV-1 Protease Inhibitors
  Journal of Biological Chemistry, 1995
• Flap opening in HIV-1 protease simulated by ‘activated’ molecular dynamics
  Nature Structural & Molecular Biology, 1995
• In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
  Nature, 1995
• Activated Dynamics of Flap Opening in Hiv-1 Protease
  Published by Springer Nature ,1995
• The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU
  Biochimie, 1991
• Active human immunodeficiency virus protease is required for viral infectivity.
  Proceedings of the National Academy of Sciences, 1988