Rapid Determination of Valproic Acid in Biological Specimens
- 1 September 1978
- journal article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 2 (5) , 207-209
- https://doi.org/10.1093/jat/2.5.207
Abstract
A new rapid method is presented for the detection and quantitation of valproic acid (dipropyl acetic acid), VPA, in biological fluids. The method involves a single microextraction of the familiar acid-tungstate filtrate for the isolation of VPA. No back extraction or cleanup steps are required. One-microliter portions of the microextract are injected on a short, 3% OV-225 glass column, maintained isothermally at 110°C. Detection is accomplished by a standard flame ionization detector. Quantitation is achieved and precision is maintained through the use of an internal standard (paramethadione) carried through the procedure.Keywords
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