Supplemental sulfone (dapsone) therapy. Use in treatment of chloroquine-resistant falciparum malaria

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Abstract
Supplemental therapy with dapsone proved highly effective in reducing recrudescence rates of Plasmodium falciparum malaria among non-immune American troops. In the present study, 41% of the malaria patients treated concurrently with both chloroquine and quinine had a recrudescence of their infection within 3 weeks, whereas only 3 of 105 patients treated initially with both chloroquine and quinine and then given supplemental therapy with dapsone for 4 weeks had a recrudescence of their illness.

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