Aberrant breakpoints in chronic myelogenous leukaemia; oncogenes and fragile sites
- 1 December 1986
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 74 (4) , 447-448
- https://doi.org/10.1007/bf00280504
Abstract
Three hundred and twenty-five aberrant breakpoints in chronic myelogenous leukaemia (CML) with Philadelphia chromosome variant were reviewed. Eight chromosomal bands (3p21, 6p21, 7p22, 11q13, 12p13, 17p13, 17q21, and 17q25) were found to be highly involved. Apart from 17q25, all these bands correspond to oncogenes sites and/or sites involved as primary breakpoints in cancer.This publication has 3 references indexed in Scilit:
- Clustering of breakpoints to specific chromosomal regions in human neoplasia. A survey of 5,345 casesHereditas, 1986
- Report of the committee on chromosome rearrangements in neoplasia and on fragile sitesCytogenetic and Genome Research, 1985
- Restricted number of chromosomal regions implicated in aetiology of human cancer and leukaemiaNature, 1984