TOPICAL 16,16-DIMETHYL PGE2 PREVENTS ALCOHOL-INDUCED DAMAGE IN CANINE GASTRIC-MUCOSA

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 89  (4) , 494-499
Abstract
Using a canin Heidenhain pouch model, the effect of pretreatment with topical administration of 16,16-dimethyl prostaglandin E2 (dmPGE2) on gastric mucosal damage induced by 15% ethanol in acid solution was studied. Ethanol alone damaged the pouches, as evidenced by large net fluxes of Na+ and K+ into the pouch, loss of H+ from the bathing solution and increased gastric perfusate volume. Topical dmPGE2 by itself had no effect on H+ or K+ flux but significantly increased Na+ flux and stimulated volume output. These effects on Na+ and volume were not increased further during exposure of the mucosa to ethanol and the changes in K+ flux and H+ loss induced by ethanol alone were prevented by dmPGE2. Topically applied dmPGE2 prevented alcohol-induced damage to canine gastric mucosa. The mechanism underlying this protection was unknown but since dmPGE2 stimulated a volume flow rich in Na+ this secretion prevented the permeation of H+ with their damaging effects on gastric mucosal cells.