Further Characterization of the Human Inducer T Cell Subset Defined by Monoclonal Antibody
Open Access
- 1 December 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 123 (6) , 2894-2996
- https://doi.org/10.4049/jimmunol.123.6.2894
Abstract
Evidence is presented that the OKT4+ T cell subset in man, defined by a monoclonal hybridoma antibody, provides help for B lymphocyte differentiation in a PWM driven system. Both B cell proliferation and intracytoplasmic immunoglobulin synthesis are facilitated by OKT4+ and not by OKT4- T cells. Given earlier studies demonstrating that OKT4+ T cells were necessary for generation of T cytotoxic cells and the present study that OKT4+ T cells are necessary for the differentiation of B cells, it would appear that the OKT4+ population is the major human T helper (inducer) subset.This publication has 0 references indexed in Scilit: