CLYDE MOOD SCALE CHANGES IN ANXIOUS OUTPATIENTS PRODUCED BY CHLORDIAZEPOXIDE THERAPY

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Abstract
The data presented demonstrate that the Clyde Mood Scale, consisting of 48 items and providing 6 derived factor scores, is not only sensitive in detecting drug-placebo differences over a 4-week period, but also consistent, for it demonstrates almost identical differences in 2 separate studies carried out with the same agent but with different dosages. In both studies differences in regression lines were observed for the same 2 factors, namely "sleepy" and "dizzy." The fact that in a multivariate analysis the same factors did not contribute significantly to chlordiazepoxide-placebo differences emphasizes the importance of looking for such regression differences. These significant differences in regression lines were, at least in this study, real and not produced by only a few deviant scores. Lastly, when the same data were analyzed by multivariate techniques, they not only demonstrated that: high and low chlordiazepoxide dosages did not produce significantly different post-scores, and the two studies did not differ significantly in treatment outcome, but also by comparing the combined drug group with the combined placebo group that larger significant drug-placebo differences could be demonstrated in this multivariate analysis than in the two single covariance analyses of the 2 individual studies, which when independently analyzed, had a smaller number of patients.

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