The action of alkyl fluorophosphonates on esterases and other enzymes

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Abstract
Brain cholinesterase was inhibited by an alkyl fluorophosphonate, but not as strongly as serum cholinesterase. Liver esterase, human milk lipase and kidney phosphatase were also sensitive to diisopropyl fluorophosphonate, though not to the same extent as cholinesterase. These enzymes were also inhibited by eserine, but there was no correlation between the sensitivity towards fluorophosphonate and towards eserine or NaF. Liver esterase in particular was highly sensitive to fluorophosphonate but relatively insensitive to eserine. The specificity of inhibition by fluorophosphonates was similar to that reported for tri-o-cresyl phosphate and tri-o-chlorophenyl phosphate. Alkyl fluorophosphonates had no effect on a number of other '' enzymes tested, with the possible exception of yeast pyrophos-phatase.