Detection of Antibodies to Toxin-Coregulated Pili in Sera from Cholera Patients
Open Access
- 1 March 2004
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (3) , 1824-1827
- https://doi.org/10.1128/iai.72.3.1824-1827.2004
Abstract
Monoclonal antibodies (MAbs) were prepared against toxin-coregulated pili (TCP) isolated from Vibrio cholerae O1 El Tor. Despite their limited bactericidal potential, two MAbs were able to mediate biotype-specific protection against experimental cholera in infant mice. These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients.Keywords
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