Hypoglycemia and Counterregulation in Insulin-Dependent Diabetic Patients: A Comparison of Continuous Subcutaneous Insulin Infusion and Conventional Insulin Injection Therapy
- 1 May 1986
- journal article
- clinical trial
- Published by American Diabetes Association in Diabetes Care
- Vol. 9 (3) , 221-227
- https://doi.org/10.2337/diacare.9.3.221
Abstract
Eleven insulin-dependent diabetic patients were treated in random order by 2-mo continuous subcutaneous insulin infusion (CSII) or 2-mo conventional injection treatment (CIT)with crossover to the alternative regimen. Mean plasma glucose concentrations throughout the day were significantly lower during CSII than during CIT, but the percentage of plasma glucose values P < .02) in the five patients on CSII who experienced frequent symptomatic hypoglycemic episodes (>4/2 mo) during CIT. Neither the plasma glucose concentration at which the patients recognizedinduced hypoglycemia nor the glycemic or counterregulatory hormone responses for 60 min thereafter were changed by CSII treatment.Keywords
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