Vago‐vagal Gastro‐gastric Relaxation in the Cat

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Abstract
In anesthetized cats electric afferent stimulation of nerve branches emanating from the gastric corpus region promptly elicited reflex gastric relaxation. The response was not blocked by atropine, guanethidine or cervical spinal cord transection but was abolished by cervical vagotomy, showing that the vagal “relaxatory” fibres to the stomach mediate this reflex effect. Transient distension of the stomach produced a long‐lasting gastric relaxation with similar characteristics as that obtained by the mentioned afferent electric stimulation. By vagal blockade in atropinized cats it was shown that the vagal nerves exerted no or only slight relaxatory effects if the stomach was only slightly filled, hut then had a profound relaxatory effect when the stomach was moderately or greatly filled. It is concluded that a vago‐vagal gastro‐gastric relaxatory reflex exists where the vagal non‐adrenergic relaxatory fibres serve as the efferent link. The reflex can be activated from gastric mechanoreceptors responding to distension and is suggested to be involved in the regulation of receptive relaxation in gastric filling.

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