Porphyrin-inducing Activity of Alfaxolone and Alfadolone Acetate in Chick Embryo Liver Cells
Open Access
- 1 April 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 50 (4) , 350-352
- https://doi.org/10.1097/00000542-197904000-00012
Abstract
The 2 steroid components of Alfathesin, alfaxalone and alfadolone acetate, have been tested for porphyrin-inducing activity in chick embryo liver cell culture and for hepatic ALA [aminolevulinic acid]-synthetase-inducing activity in the 17 day old chick embryo. In cell culture alfaxalone had potency comparable to that of thiopental, while alfadolone acetate had low potency. In the 17 day old chick embryo alfaxalone has a 3rd the potency of thiopental; alfadolone acetate showed low potency. An induction dose of Alfathesin may be less likely than a comparable dose of thiopental to increase ALA-synthetase activity in a patient with hereditary hepatic porphyria.Keywords
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