Ovum Implantation and Uterine Lysosomal Enzyme Activity

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Abstract
Uterine cathepsin D activity (EC 3.4.4.b) and β-glucuronidase activity (β-D-glucoside glucohydrolase, EC 3.2.1.24) were determined in ovum implantation sites during early pregnancy. Within 24 h after implantation, cathepsin D activity decreased 50% at the implantation site; there was no change in β-glucuronidase activity. Neither cathepsin D activity nor β-glucuronidase activity increased during early pregnancy before the time of implantation. The presence of a thread in the uterine lumen had no effect on cathepsin D activity. In ovariectomized rats, both estradiol and progesterone increased cathepsin D activity, but estradiol was twice as effective in increasing the enzyme activity.

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