Urinary Excretion of Catecholamines and Their Metabolites in Patients with Renovascular Hypertension

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Abstract
Urinary excretion of catecholamines, vanillylmandelic acid and methoxycatecholamines was studied in 50 patients with renovascular hypertension. Urinary excretion of noradrenaline [norepinephrine] was increased in patients with elevated peripheral plasma renin activity and in those with elevated renal vein renin ratio compared with patients with normal plasma renin activity. Urinary excretion of dopamine was diminished and vanillylmandelic acid increased in all patients with renovascular hypertension. Following dietary Na restriction, the mean urinary excretion of noradrenaline increased and dopamine excretion decreased. Increased sympathetic activity may play a role in the pathogenesis of renovascular hypertension.

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