Continuous Particle Separation Through Deterministic Lateral Displacement
Top Cited Papers
- 14 May 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5673) , 987-990
- https://doi.org/10.1126/science.1094567
Abstract
We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on the basis of its size. All particles of a given size follow equivalent migration paths, leading to high resolution. The microspheres of 0.8, 0.9, and 1.0 micrometers that were used to characterize the device were sorted in 40seconds with a resolution of ∼10nanometers, which was better than the time and resolution of conventional flow techniques. Bacterial artificial chromosomes could be separated in 10 minutes with a resolution of ∼12%.Keywords
This publication has 19 references indexed in Scilit:
- Size-exclusion chromatography using self-organized nanopores in anodic porous aluminaApplied Physics Letters, 2003
- On-Chip Hydrodynamic Chromatography Separation and Detection of Nanoparticles and BiomoleculesAnalytical Chemistry, 2003
- Tilted Brownian Ratchet for DNA AnalysisAnalytical Chemistry, 2003
- A DNA prism for high-speed continuous fractionation of large DNA moleculesNature Biotechnology, 2002
- Rapid Pulsed Field Capillary Electrophoretic Separation of Megabase Nucleic AcidsAnalytical Chemistry, 1995
- Directional motion of brownian particles induced by a periodic asymmetric potentialNature, 1994
- Field-Flow Fractionation: Analysis of Macromolecular, Colloidal, and Particulate MaterialsScience, 1993
- Separation by FlowMacromolecules, 1970
- ‘Eddy’ Diffusion in ChromatographyNature, 1959
- On the dispersion of a solute in a fluid flowing through a tubeProceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences, 1956