Comparison of ranitidine 300 mg twice daily, 300 mg at night and placebo on 24‐hour intragastric acidity of duodenal ulcer patients

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Abstract
SUMMARY: Continuous measurement of 24‐hour intragastric acidity was performed in 12 duodenal ulcer patients in remission during treatment with placebo, ranitidine 300 mg nocte and ranitidine 300 mg b.d. Median 24‐hour acidity was 79.4 mmol litre−1 during placebo treatment; it decreased to 28.2 mmol litre−1 during treatment with ranitidine 300 mg nocte and to 3.6 mmol litre−1 during treatment with ranitidine 300 mg b.d. The two regimens decreased intragastric acidity to a similar degree during the night, but significantly greater inhibition of daytime and 24‐hour acidity followed use of ranitidine 300 mg b.d.