Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.
- 1 December 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (24) , 7824-7827
- https://doi.org/10.1073/pnas.79.24.7824
Abstract
Human sequences related to the transforming gene (v-myc) of avian myelocytomatosis virus (MC29) are represented by at least one gene and several related sequences that may represent pseudogenes. By using a DNA probe that is specific for the complete gene (c-myc), different somatic cell hybrids possessing varying numbers of human chromosomes were analyzed by the Southern blotting technique. The results indicate that the human c-myc gene is located on chromosome 8. The analysis of hybrids between rodent cells and human Burkitt lymphoma cells, which carry a reciprocal translocation between chromosomes 8 and 14, allowed the mapping of the human c-myc gene on region (q24 leads to qter) of chromosome 8. This chromosomal region is translocated to either human chromosome 2, 14, or 22 in Burkitt lymphoma cells.This publication has 31 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patientNature, 1982
- Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor stateCell, 1981
- The origin of human cancersNature, 1981
- 2/8 translocation in a Japanese Burkitt's lymphomaCellular and Molecular Life Sciences, 1979
- Studies on the association of the Epstein-Barr virus genome and human chromosomesJournal of Cellular Physiology, 1978
- Continuous growth and differentiation of human myeloid leukaemic cells in suspension cultureNature, 1977
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977
- Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomasInternational Journal of Cancer, 1976
- A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa StainingNature, 1973