A clinical isolate of Escherichia coli owing its trimethoprim resistance to a chromosomally-located trimethoprim transposon

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Abstract
A strain of Escherichia coli isolated from infected urine was shown to owe its high-level trimethoprim resistance of 1024 mg/l to a chromosomally-located trimethopnm-streptomycin transposon. This transposon closely resembled those reported previously to be located on transferable trimethoprim R plasmids. The isolation frequency of similar high-level chromosomally-resistant strains seems to be increasing and may reflect an increasingly important cause of trimethoprim resistance.