A SIMPLE SCREENING TEST FOR HISTIDINURIA

1 January 1969

journal article
Published by American Academy of Pediatrics (AAP) in Pediatrics

Vol. 43 (1) , 40-43
https://doi.org/10.1542/peds.43.1.40

Abstract

Histidinemia, a childhood disease associated with mental retardation, can be identified by the presence of histidinuria. A rapid and simple screening test for histidinuria has been developed by the authors and is based on the inhibition by histidine of the blue color formed by the reaction of cupric ion and bis-cyclohexanone oxaldihydra-zone. The formation of a colorless solution in this test should identify all urine specimens in which the concentration of histidine is greater than 60 mg/l00 ml and most specimens in which the concentration of histidine is greater than 20 mg/100 ml. By appropriate dilution of a urine sample, the screening test may be used to estimate, semi-quantitatively, the concentration of histidine in urine.

Keywords

This publication has 0 references indexed in Scilit: