Brain-tissue cysts in rats infected with the RH strain ofToxoplasma gondii
- 1 January 1992
- journal article
- Published by Springer Nature in Zeitschrift Fur Parasitenkunde-Parasitology Research
- Vol. 78 (3) , 267-269
- https://doi.org/10.1007/bf00931740
Abstract
Virulent strains of the coccidian parasiteToxoplasma gondii become attenuated so as to survive and complete their life cycle; however, it is not known whether the attenuation process is attributable to an innate cystogenic capacity of the parasite or to host-induced mechanisms. This report presents direct evidence of RH cystogenesis in non-immunised Fischer rats and subsequent attenuation of RH pathogenicity in non-immunised mice following a single passage through rats. Taken together, these preliminary observations tend to suggest that at least one mechanism ofT. gondii involves intermediate host attenuation.Keywords
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