Structure–activity relationship of inhibitors of hydroxyapatite formation

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Abstract
Organic diphosphates, fructose 1,6-bisphosphate, pyrophosphate, imidodiphosphate and 3-phosphoglycerate all inhibited the transformation of amorphous calcium phosphate into hydroxylapatite to various degrees. Strong inhibition was seen with phosphonoformate, and phosphocitrate was the most powerful of the inhibitors studied. An improved concept of the structure-activity relationship of inhibitors is proposed and mechanisms for inhibitor action are discused.