A study on melanogenesis and catecholamine biosynthesis duringBufo bufo development

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Abstract
Tyrosinase and L‐DOPA decarboxylase activities have been investigated during Bufo bufo development since catecholamines and melanin are formed from common substrates in homologous cells. Catecholamines first appear at stage 13 (neural plate), but tyrosinase, at a very low level, and L‐DOPA decarboxylase are present throughout all of prior development. Hence, L‐DOPA decarboxylase activity is not likely to be correlated with the control of catecholamine synthesis, although at stage 17 it is mainly localized in the nonneural part of the embryo. The distribution of young melanosomes and L‐DOPA decarboxylase suggest a separation between melanogenesis and catecholamine synthesis.