Skin Collagen Biosynthesis In Patients With Rheumatoid Arthritis Treated With D-Penicillamine
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 8 (2) , 124-128
- https://doi.org/10.3109/03009747909105350
Abstract
Collagen biosynthesis was measured in skin biopsies taken from 13 patients with rheumatoid arthritis before and after at least 6 months' continuous treatment with D-peniciilamine, 1.0 g/day. There was a significant 36% reduction in mean collagen biosynthesis (p14C-hydroxyproline formation from 14C-proline during 24 h of tissue culture. The changes in 14C-hydroxy-proline formation were correlated with the total doses of D-penicillamine taken (r=0.71, pr=0.72, pin vitroinhibited both collagen and general protein synthesis (p<0.01). It is suggested that the clinical improvement induced by D-penicillamine could reflect an inhibition of collagen proliferation in the synovium.This publication has 11 references indexed in Scilit:
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