INCREASED D-GLUCARIC ACID EXCRETION IN CHILDREN WITH RENAL-DISEASE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 18  (8) , 357-360
Abstract
In 85 infants and children, non-specific microsomal enzyme activity was assessed by measuring the urinary D-glucaric acid excretion. In patients with renal disease of various etiology, a highly significant increase in the D-glucaric acid excretion was observed at an early stage of the illness. This change was most marked in patients suffering from tubulopathy and pyelonephritis. Excretion of D-glucaric acid was significantly more prononunced in patients with renal disease than in controls, even in those groups of infants and children who were given enzyme-inducing drugs. As an explanation for the elevation of urinary D-glucaric acid levels in patients with mild renal disease, the possibility biochemical mechanism of an induction of drug metabolizing enzymes are discussed and some therapeutic conclusions are drawn.