Experimental thyroiditis in the rhesus monkey. IV. The role of thyroglobulin and cellular antigens.

  • 1 February 1968
    • journal article
    • Vol. 3  (2) , 133-51
Abstract
Nine normal rhesus monkeys were injected with homologous thyroid preparations, consisting either of a crude extract, partially purified thyroglobulin, or enzymatically dispersed viable cells. One monkey was injected with a preparation of heterologous human thyroid microsomes. The course of the disease was followed by periodic biopsies of the thyroid gland and by circulating antibodies. The latter were detected by tanned cell haemagglutination, complement fixation and cytotoxicity. The serum was also examined for levels of complement and for thyroid hormones.