In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum.
- 1 May 1992
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 33 (5) , 517-520
- https://doi.org/10.1111/j.1365-2125.1992.tb04081.x
Abstract
The in vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline was compared against chloroquine‐resistant and ‐ susceptible strains of Plasmodium falciparum using a semi‐micro drug susceptibility test. For each strain, the corresponding enantiomers exhibited similar activities. The enantiomers of halofantrine were the most active against both susceptible and resistant strains, followed by the enantiomers of mefloquine and enpiroline.Keywords
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