Assessment of cerebral perfusion by first-pass, dynamic, contrast-enhanced, steady-state free-precession MR imaging: an animal study.

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Abstract
The purpose of this study was to determine whether cerebral perfusion could be assessed with a conventional 1.5-T MR imaging system by applying a steady-state free-precession (SSFP) technique during bolus IV injection of contrast material (gadoteridol). Normal and abnormal perfusion states and the effect of the dose of contrast material were studied in cats.Nine healthy anesthetized cats were imaged after administration of 0.5 mmol/kg (n = 5), 0.25 mmol/kg (n = 2), and 0.1 mmol/kg (n = 2) of gadoteridol. Six cats with an acute infarct of the middle cerebral artery (five cats 10 min after and one cat 1 hr after vessel occlusion) were evaluated at a dose of 0.5 mmol/kg. The middle cerebral artery was ligated in each instance by use of a snare placed around the vessel during surgery, which was performed via a transorbital approach. Each animal was imaged with spin-echo T2-weighted (3000/45,90 [TR/TE]) and T1-weighted (500/10) techniques before contrast material was injected. SSFP images (12/18, 80 degrees ti...

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