Preemptive Therapy in Immunocompromised Hosts

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Abstract
TRANSPLANTATION, of both bone marrow and solid organs, must be regarded as one of the great success stories of 20th-century biomedical science. At the same time, it must be recognized that the manipulations required to achieve long-term graft function create a series of biologic and clinical phenomena affecting the recipients that are without precedent in clinical medicine. Paramount among these are the interactions among immunologically active cells capable of responding to and destroying foreign tissue, immunosuppressive therapy aimed at controlling these cells, and certain infectious agents that are modulated by both factors.In patients undergoing bone marrow transplantation, the best . . .

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