Modeling reproductive toxicity in Ceriodaphnia tests
- 1 April 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Environmental Toxicology and Chemistry
- Vol. 12 (4) , 787-791
- https://doi.org/10.1002/etc.5620120421
Abstract
A model for Ceriodaphnia dubia reproductive toxicity outcomes is presented. This model assumes that the number of young is a Poisson‐distributed random variable and that the mean number of young can be modeled using an exponential term involving a polynomial in the test concentrations. Given these assumptions, a modeling procedure for reproductive outcomes is developed and is used to derive an estimate of potency of the chemical under test. Confidence intervals for this estimate are obtained using a bootstrap resampling procedure.Keywords
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