Immunogenic Properties of a Soluble Tumor-Specific Transplantation Antigen Induced by Simian Virus 40
- 1 January 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 52 (1) , 259-264
- https://doi.org/10.1093/jnci/52.1.259
Abstract
Soluble tumor-specific transplantation antigen was obtained from dissociated tumor cells of the ascites or tissue-cultured BALB/c lines (mKSA) transformed by simian virus 40. Immunogenic activity as assayed by tumor rejection was clearly recovered in 50% yield in the crude membrane preparation and in at least 5% yield in the crude soluble preparation. This activity was specific. After chromatography on Sephadex G-150, this activity was preserved. Contrary to other studies, we were unable to use in vitro assays of cytotoxicity to monitor solubilization and purification of this antigen.Keywords
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