PRECONVULSIVE PAROXYSMAL ELECTROENCEPHALO-GRAPHIC CHANGES AFTER METRAZOL INJECTION*

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Abstract
The authors report a method for the study of the min. eeg. response to the intraven. injn. of metrazol. In a series of 56 rabbits, this min. response occurred when from 0.2-2.2 cc. of a 1% metrazol soln. was injd. at the rate of 1 cc. per min. The avg. was 0.9 cc. The convulsive doses of metrazol in these animals ranged from 1.6-5.5 cc, avg. 3.4. The convulsive threshold tended to rise with repeated seizures, but this was not true of the min. eeg. response. Factors tending to alter the convulsive threshold, such as phenobarbital and dilantin, had the same effect on the min. response, but the relationship was not strictly proportional. The min. response in human epileptics was obtained at lower doses than in the normal patient.