Effect of TRK-100, a prostacyclin analogue, on endotoxin-induced enhancement of blood coagulation in rats.
- 1 January 1989
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 51 (3) , 450-454
- https://doi.org/10.1254/jjp.51.450
Abstract
TRK-100 (0.03, 0.1 and 0.3 mg/kg, p.o.), a chemically stable analogue of prostacyclin, dose-dependently prevented blood coagulation and glomerular fibrin deposition which were enhanced by 4 hr infusion of endotoxin (100 mg/kg) in rats. In addition, TRK-100 suppressed the generation of endotoxin-induction tissue thromboplastin like activity in cultured human endothelial cells.This publication has 0 references indexed in Scilit: