Controlling the Ups and Downs of Synaptic Strength
- 14 May 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5673) , 973-974
- https://doi.org/10.1126/science.1098805
Abstract
Neuroscientists have long been puzzled by the fact that N -methyl--aspartate (NMDA) receptors can both boost and dampen synaptic efficiency in the brain. In their Perspective, Bliss and Schoepfer reveal specific roles for NMDA receptor subtypes. According to new work ( Liu et al.), the NMDA receptor supports either long-term potentiation or long-term depression, depending on whether the receptor contains NR2A or NR2B subunits, respectively.Keywords
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