Synthesis of 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole derivatives and their central nervous system activities

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Abstract
The synthesis and some pharmacological effects [in mice] of cis- and trans-2-substituted 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3,-b]indole derivatives are described. In the derivatives, the substituents of the 2, 5 and 8 position and the relative configuration of the 4a and 9b position influenced the potency of the CNS activities. A cis-2-[3-(p-fluorobenzoyl)propyl] analog of carbidine possessed not only thymoleptic-like biological activity but had more potent neuroleptic activity than the parent drug.

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