HLA‐linked SB antigens in Israel

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Abstract
In the present study we have investigated the HLA‐SB antigen distribution in 65 unrelated Israeli Ashkenazim and non‐Ashkenazim and in a panel of 18 local homozygous typing cells (HTC). Two locally derived SB reagents, anti‐SB2 and SB3, were also studied. The HLA‐SB allele frequencies in the Israeli sample ranged from 0.02 for SB1 to 0.47 for SB4 while SB5 was absent. SB3 had a higher frequency in non‐Ashkenazim (0.11) as compared to Ashkenazim (0.06) but this difference was not significant. On the whole, the allele frequencies for the 5 HLA‐SB antigens studied were in the range observed in non‐Jewish Caucasoid populations with some minor variations. Two of eighteen local HTC's were found heterozygous for SB, demonstrating that homozygosity for HLA‐A, B, C, D and DR does not indicate homozygosity for HLA‐SB. The local anti‐SB2 and SB3 typing reagents gave concordant results when compared with the NIH reference typing cells in population studies.