Quenching of singlet oxygen by haematoporphyrin derivative (and haematoporphyrin) and its consequences on the efficiency of photodynamic cancer therapy
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 17,p. 1197-1198
- https://doi.org/10.1039/c39880001197
Abstract
Haematoporphyrin derivative used in photodynamic therapy and haematoporphyrin quench singlet oxygen that they produce (rate constants 5 × 108 and 8 × 108 dm3 mol–1 s–1, respectively) with the consequence that in photodynamic therapy an increase of the sensitizer concentration may induce a very noticeable reduction of the efficiency of the photo-oxidative damage to tumour cells.Keywords
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