Specificity of Enhanced Immunological Sensitization of Mice Following Injections of Antigens and Specific Antisera.

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Abstract
An enhanced antibody response to bovine serum albumin and fluid tetanus toxoid was found in mice when these antigens were injected in slight antigen excess with specific rabbit antisera. The specificity of the enhanced response was limited to specific antigens in complex. An enhanced response was also demonstrated to rabbit gamma globulin by testing the capacity of passively immunized mice to degrade I131 -labeled RGG at an accelerated rate. Since the enhancing effect is derived from the antigen-antibody complex per se, enhancement may result from prolonged retention of antigen, increased molecular size due to complexing or preferential localization of complexed antigen by immunologically competent cells.