In vitrosusceptibility and resistance ofCandidaspp. to hamycin
- 1 January 1971
- journal article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 9 (3) , 256-262
- https://doi.org/10.1080/00362177185190511
Abstract
Studies on hamycin susceptibility of 84 Candida strains showed that all the strains tested had a minimal inhibitory concentration of 0·16 μg/ml or under. It was possible to develop a high degree of in vitro resistance to hamycin in strains of C. albicans and C. tropicalis. Hamycinresistant variants did not exhibit any cross-resistance to nystatin and amphotericin B. A complete to partial loss of resistance was observed in all hamycin-resistant strains after repeated transfers in antibiotic-free medium. A majority of resistant variants showed alterations in some of their morphological and cultural properties.Keywords
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