Biochemical lesions in vitamin B deficiency

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Abstract
Brain tissue from poly-neuritic pigeons (vitamin B1 deficiency) shows in vitro a lowered power of O uptake in the presence of glucose as substrate. This is the case when symptoms are prolonged in all parts of the brain except the cerebellum. Control birds of equal weight to the avitaminous, but previously dosed with vitamin B1, and birds which have been cured by dosing with vitamin B1, do not show the same depression of oxidation, which is therefore associated with the specific deficiency. The symptoms of opisthotonus are associated with chemical changes in certain parts of the brain and are central rather than peripheral in origin.