Infectious Bursal Disease Viral Infections. II. The Relationship of Age, Complement Levels, Virus-Neutralizing Antibody, Clotting, and Lesions

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Abstract
Experimental infection with infectious bursal disease virus (IBDV) reduced the complement (C) titer in 8 wk old chickens on days 3, 5 and 7 post-infection. Since the C titer was much lower in normal 2 wk old chickens than in normal 8 wk old chickens it could not be determined whether there was a reduction in titer during the infection process. Virus-neutralizing antibody rose rapidly following infection in 2 and 8 wk old chickens. Hyperimmune serum given during infection to produce immune complexes did not increase disease severity in 2 or 6 wk old susceptible chickens.