Qualitative and Quantitative Changes of Collagen in Parenchymatous Organs of the Rat During Ageing

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Abstract
With the hydroxyproline test, it was shown that the collagen in the connective tissue of parenchymatous organs ages in the same manner as the collagen in muscles, tendons and in the corium of the skin. By thermic contraction about 30% hydroxyproline containing complexes are dissolved in young animals, but only 1-4% in old ones. The speed of the decrease of "labile collagen" is different in kidney, lung and liver. The growth rate for collagen is greater than for the parenchymatous organs during the whole life. In the 3 organs the collagen concentration becomes nearly threefold in age. The absolute amount of collagen increases too in the 3 organs with age. The factors which are important for the stated age changes are discussed.