Effect of SO2 on the Pathogenesis of Viral Upper Respiratory Infection in Mice

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Abstract
The effects of constant exposure of nasal mucous membranes in mice to low levels of SO2 on the pathogenesis of influenza virus infection in these animals were studied. Increased severity of influenza infection after continued exposure to low levels of SO2 apparently resulted from a progressive alteration of the nasal mucous membranes by SO2 which then allowed rapid destructive proliferation of subsequently introduced virus. This destruction of nasal tissues would eliminate a major defensive barrier against lower tract disease.

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