A Rapid and Specific Method for the Determination of Tiaprofenic Acid in Human Plasma by High-Performance Liquid Chromatography

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Abstract
A method has been developed to assay tiaprofenic acid in human plasma. The technique is rapid, specific and sensitive, being capable of detecting 0.5′ μg ml−1 and requiring only 200 μl of plasma for a single assay. Samples are deproteinized, extracted into chloroform and then, after evaporation of the chloroform and reconstitut ion in the mobile phase, are chromatographed by reverse phase liquid chromatography.