Metabolites and Analogues of Vitamin D
- 12 February 1982
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 247 (6) , 841-844
- https://doi.org/10.1001/jama.1982.03320310085047
Abstract
The discovery and chemical synthesis of several biologically active derivatives of vitamin D have increased the number of compounds available for the treatment of disorders of bone and mineral metabolism. Calcitriol is the most active natural metabolite of vitamin D, but analogues like dihydrotachysterol and calcifediol also are safe and effective therapeutic agents. These vitamin D congeners have been useful in the treatment of renal osteodystrophy, hypoparathyroidism, and other disorders refractory to vitamin D therapy. Certain analogues may offer distinct advantages over vitamin D, depending on the nature of the defect. All vitamin D derivatives should be used cautiously, with frequent monitoring of serum calcium levels to prevent toxic reactions. (JAMA1982;247:841-844)Keywords
This publication has 2 references indexed in Scilit:
- Vitamin D Metabolism and the Response to 1,25-Dihydroxycholecalciferol in OsteoporosisJournal of Clinical Endocrinology & Metabolism, 1977
- Comparison between Crystalline Dihydrotachysterol and Calciferol in Patients Requiring Pharmacologic Vitamin D TherapyNew England Journal of Medicine, 1967