Role of the Yersinia pestis Hemin Storage ( hms ) Locus in the Transmission of Plague by Fleas
- 19 July 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 273 (5273) , 367-370
- https://doi.org/10.1126/science.273.5273.367
Abstract
Yersinia pestis, the cause of bubonic plague, is transmitted by the bites of infected fleas. Biological transmission of plague depends on blockage of the foregut of the flea by a mass of plague bacilli. Blockage was found to be dependent on the hemin storage (hms) locus. Yersinia pestis hms mutants established long-term infection of the flea's midgut but failed to colonize the proventriculus, the site in the foregut where blockage normally develops. Thus, the hms locus markedly alters the course of Y. pestis infection in its insect vector, leading to a change in blood-feeding behavior and to efficient transmission of plague.Keywords
This publication has 22 references indexed in Scilit:
- Expression of two csg operons is required for production of fibronectin‐ and Congo red‐binding curli polymers in Escherichia coli K‐12Molecular Microbiology, 1995
- The pigmentation locus of Yersinia pestis KIM6+ is flanked by an insertion sequence and includes the structural genes for pesticin sensitivity and HMWP2Molecular Microbiology, 1994
- Melanogenesis and the Generation of Cytotoxic Molecules During Insect Cellular Immune ReactionsPigment Cell Research, 1993
- Proteins essential for expression of the Hms+ phenotype of Yersinia pestisMolecular Microbiology, 1993
- Defense mechanisms in insects: Certain integumental proteins and tyrosinase are responsible for nonself‐recognition and immobilization of Escherichia coli in the cuticle of developing Ceratitis capitataArchives of Insect Biochemistry and Physiology, 1993
- Loss of the pigmentation phenotype in Yersinia pestis is due to the spontaneous deletion of 102 kb of chromosomal DNA which is flanked by a repetitive elementMolecular Microbiology, 1992
- Analysis of Yersinia pestis chromosomal determinants Pgm+ and Psts associated with virulenceMicrobial Pathogenesis, 1992
- Insect Cuticle SclerotizationAnnual Review of Entomology, 1992
- Contemporary Views on the Interrelationships Between Fleas and the Pathogens of Human and Animal DiseasesAnnual Review of Entomology, 1977
- Studies on Pasteurella pestis in Fleas: II. Experimental Blocking of Xenopsylla cheopis with an Avirulent Strain of P. pestisScience, 1954