The Variations of Plasma Corticosterone/Cortisol Ratios Following ACTH Stimulation or Dexamethasone Administration in Normal Men
- 1 September 1977
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 45 (3) , 585-588
- https://doi.org/10.1210/jcem-45-3-585
Abstract
A radioimmunoassay for human plasma corticosterone has been developed. Plasma corticosterone increased 4.83 times as much as basal value at 60 min after an im injection of 0.25 mg synthetic β1–24 ACTH® (Cortrosyn) in normal subjects, whereas plasma cortisol increased 2.12 times as much at 60 min. And basal corticosterone/cortisol ratio of 0.053 ± 0.017 increased to 0.116 ± 0.022 (P < 0.001) after ACTH. This might be mainly due to a larger increment of corticosterone than that of cortisol after ACTH. Corticosterone decreased to 36.7% of basal value at 4 h after 1 mg dexamethasone administration in normal subjects, whereas cortisol decreased to 13.9% of basal value at 4 h. The basal corticosterone/ cortisol ratio of 0.059 ± 0.020 increased to 0.137 ± 0.055 (0.001 < P < 0.01) after dexamethasone administration.This may have been mainly due to a more effective suppression of cortisol than that of corticosterone after dexamethasone.Keywords
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